When leg pain coincides with the menstrual period, it often suggests a connection to the female cycle. However, it is essential to consider that leg pain can also result from injuries or overuse, which may coincide with the period or intensify during certain cycle phases. Hormone levels, including progesterone, estrogen, and pain messengers like prostaglandins, fluctuate throughout the menstrual cycle. During the period, estrogen and progesterone levels are low, while prostaglandin production increases towards the end of the period [4]. These hormonal shifts may explain why leg pain becomes more noticeable during menstruation. Additionally, orthopedic factors related to nerves, muscles, and intervertebral discs must be considered. Nevertheless, persistent cycle-related pain episodes should prompt consideration of endometriosis as a potential diagnosis or cause.

For more information about the symptoms of endometriosis, you can explore the Endo-App to learn about the condition and available options.