Today, I aim to delve into the complexities of this intricate system, exploring its functioning and how external factors can influence it.
Furthermore, I will elucidate how the body manufactures its own pain-relieving agents, referred to as endocannabinoids.
Back in 1992, scientists at the National Institute of Mental Health were the pioneers who first uncovered the existence of the endocannabinoid system (ECS) [1].
Subsequent years and decades saw significant strides in scientific understanding, shedding light on the intricacies of this complex system.
Here is what we already comprehend about it:
The captivating system relies on the engagement of 2 distinct receptor types, essentially acting as locks that can only be opened by specific keys. These keys are represented by CB1 and CB2 receptors. They are dispersed throughout the body, each type with its own preferred location. CB1 receptors are predominantly concentrated in the brain and central nervous system [4].
When cannabinoids such as tetrahydrocannabinol (THC) are consumed, CB1 receptors come into play, giving rise to psychoactive effects, often referred to as the “high.” On the contrary, CB2 receptors are less widespread and are mainly found in immune cells and selected neurons [4].
Although ongoing research aims to uncover additional tissues that might also be influenced through receptors, our current knowledge is still unfolding.
Yet, at present, we have only unveiled the “locks.” The corresponding “keys” are cannabinoids. These are chemical messengers that can be introduced from external sources or generated within the body itself. Scientists differentiate between endogenous and exogenous forms of cannabinoids.
Cannabinoids play a pivotal role in activating the endocannabinoid system and can yield desirable outcomes. This process is exemplified by endocannabinoids, which your body produces naturally. These compounds are reputed to exert highly specific effects on mood, appetite, sleep, and more. Termed endocannabinoids, they originate from fatty acids within your body [1].
The following endocannabinoids have been subject to thorough exploration:
Endocannabinoids are generated by your body on an as-needed basis, preserving their availability for critical moments. Anandamide production is initiated within tissues and cell membranes, guided by the body’s cues. Additional endocannabinoids have also captured researchers’ attention. While anandamide and 2-arachidonylglycerol (2-AG) hold significance, there is much to unravel regarding other compounds of this kind [1].
Phytocannabinoids, known as exogenous cannabinoids, hail from plants and likewise interact with the endocannabinoid system [9]. Prominent examples include tetrahydrocannabinol (THC) and cannabidiol (CBD), both derived from the hemp plant and capable of eliciting physiological effects.
Divergence arises between THC and CBD in terms of their impact. THC triggers intoxicating sensations, while CBD does not. As a result, cannabidiol is under intensive investigation, and numerous dietary supplements featuring CBD are available on the market. It is crucial, however, that these products contain a maximum of 0.2% THC content to prevent intoxicating effects. Adhering to this stipulation ensures that CBD full-spectrum products are legally obtainable and consumable in Germany [10].
In the realm of scientific exploration, an intriguing study has delved into the intricate connection between endocannabinoids—naturally produced by the body—and their association with endometriosis.
Researchers are positing a hypothesis that these substances might exert a pain-modulating influence. The intricacies of pain control mechanisms in relation to endometriosis remain a subject necessitating further research. A pivotal contribution to this discourse has been made through a detailed examination of the endocannabinoid 2-AG (2-arachidonoylglycerol). Conventionally, it has been assumed that this compound binds to specific receptors situated on nerve cell membranes, thus influencing pain perception. The prevailing notion suggests that heightened concentrations of 2-AG could potentially attenuate pain sensations [11]. Nevertheless, the findings from the particular study took an unexpected trajectory [12].
The endocannabinoid system’s involvement in endometriosis remains intricate and incompletely understood. However, there seem to be intriguing connections poised for further exploration in the forthcoming years.
This very process potentially triggers the pain linked to the inflammatory response. In this light, endocannabinoids appear to exhibit a dual nature. On one hand, they seemingly possess the ability to alleviate pain, while on the other, they engage the immune system, potentially exacerbating pain sensations [10]. Ultimately, a deeper comprehension of these complex dynamics could aid not only in the enhanced diagnosis of endometriosis but also in facilitating more effective treatment strategies.
However, direct patient studies are somewhat lacking. Nevertheless, some researchers hold the view that targeting the endocannabinoid system holds promise for treating endometriosis-related pain [14]. As previously mentioned, this intricate system can be influenced by the external application of cannabinoids. Specifically, both THC and CBD are worth considering in this context.
In a survey involving endometriosis patients aged between 18 and 45 years, 484 responses were gathered via an online platform. Among these respondents, 76% had employed self-administered strategies to manage their endometriosis symptoms over the past 6 months.
Of note, cannabis was chosen as a strategy by 13% of these women. They reported experiencing notably reduced pain as a result. Additionally, improved sleep quality and relief from nausea and vomiting were also noted.
However, it is important to weigh the potential downsides when considering tetrahydrocannabinol. Undesirable effects such as fatigue, reduced concentration, or general cognitive impairment must be carefully considered. Given THC’s intoxicating effect, its usage could impact activities such as operating machinery or driving [15].
Earlier studies have indicated that cannabidiol may possess analgesic, anti-inflammatory, anxiolytic, and sedative properties [16, 17, 18, 19]. Consequently, these extracts could hold potential for endometriosis patients. However, studies that provide clear actionable recommendations for those affected are still somewhat lacking. Nevertheless, the option of using CBD oil remains, allowing individuals to personally explore whether symptoms improve with its use.
In this country, doctors have been authorized to prescribe cannabis since 2017. Cannabis in the form of dried flowers or extracts can be prescribed for medical use. Furthermore, there are pharmaceutical options containing dronabinol and nabilone, active ingredients that are partially or fully synthetic variations. However, to qualify for a cannabis prescription, one of the following conditions must be met [20]:
Contrasting tetrahydrocannabinol, cannabidiol is readily accessible and can be legally consumed if its THC remains below 0.2%, and it is a full-spectrum oil – meaning CBD content aligns with the plant’s composition [8].
Acquiring THC from the store is not feasible; however, cannabidiol is an exception. A broad range of options is now available in pharmacies or online. You will observe that CBD oil products vary in potency, indicated by different percentages.
Generally, higher percentages demand fewer drops for potential effect. Yet, it is crucial to recognize that what you are obtaining is a dietary supplement, not a medicine, and no promises of effect or cure can be guaranteed. The decision to explore the potential of cannabidiol rests with you.
Various forms of CBD are at your disposal:
Due to its potency and ease of use, many opt for CBD oil. The application is straightforward – place a few drops under the tongue, wait a few minutes, and then swallow. The oral mucosa efficiently absorbs the herbal extracts.
Note: When acquiring a CBD product, you are purchasing a consumable. Occasionally, these oils are labeled as cosmetics to circumvent stringent food regulations. However, this can lead to receiving a product that does not meet the legal requirements, potentially due to excessive THC content, in the worst-case scenario.
The World Health Organization (WHO) confirms that cannabidiol (CBD) is generally well-tolerated and does not pose a risk for abuse [21].
Common side effects may include dry mouth, drowsiness, or dizziness. In such instances, it is advisable to consider a slight reduction in dosage.
CBD has the potential to interact with the body’s natural enzymes, affecting the potency of certain medications. This interaction has been particularly noted with acid inhibitors, anticoagulants, pain relievers, and neuroleptics.
Given these considerations, it is recommended to engage in a discussion with your healthcare provider before incorporating CBD oil into your routine.
Hinterlasse uns gerne einen Kommentar, wenn du schon Erfahrungen mit Cannabinoiden gesammelt hast.
Psychologist Teresa Götz (Endo-App) interviewed Dr. Cecilia Ng, who is doing research on endometriosis in…
Psychologist Teresa Götz (Endo-App) interviewed Dr. Cecilia Ng, who is doing research on endometriosis in…
Psychologist Teresa Götz (Endo-App) interviewed Dr. Cecilia Ng, who is doing research on endometriosis in…
Psychologist Teresa Götz (Endo-App) interviewed Dr. Cecilia Ng, who is doing research on endometriosis in…
Psychologist Teresa Götz (Endo-App) interviewed Dr. Cecilia Ng, who is doing research on endometriosis in…
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